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Bellingham Veterinary


Allogeneic peripheral blood haematopoietic stem cell transplantation for the treatment of dogs with high-grade B-cell lymphoma

Abstract: Autologous peripheral blood haematopoietic stem cell transplantation (HCT) cures 33%-40% of dogs with high-grade B-cell lymphoma. We hypothesized, based on human allogeneic bone marrow transplantation literature, that transplanting dogs using canine donor leukocyte-matched CD34+ cells would lead to fewer relapses and increased cure rates. We retrospectively reviewed medical records of dogs diagnosed with high-grade B-cell lymphoma who received an identical allogeneic HCT. A total of 15 dogs transplanted at four facilities were identified. Five of fifteen dogs relapsed before transplant. The mean number of donor CD34+ cells/kg harvested and infused into recipient dogs was 8.0 × 106 /kg (range: 2.08 × 106 /kg-2.9 × 107 /kg). The median disease-free interval and overall survival of all dogs was 1095 days (range: 9-2920 days) and 1115 days (range: 9-2920 days), respectively. Two of five dogs, not in remission at transplant, died in the hospital. The median disease-free interval and overall survival of the remaining three dogs was 25 days (range: 15-250 days) and 1100 days (range: 66-1902 days), respectively. The median disease-free interval and overall survival of the 10 dogs who had not relapsed was 1235 days (range: 19-2920 days) and 1235 days (range: 19-2920 days), respectively. One dog died soon after discharge of presumed gastric-dilatation-volvulus. Eight of nine remaining dogs lived >4 yrs post-alloHCT, leading to a cure rate of 89%. Acute graft versus host disease was seen in three dogs. These results suggest that allogeneic HCT can cure ~50% more dogs than those treated with autologous HCT.

Gareau A, Sekiguchi T, Warry E, Ripoll AZ, Sullivan E, Westfall T, Chretin J, Fulton LM, Harkey M, Storb R, Suter SE. Allogeneic peripheral blood haematopoietic stem cell transplantation for the treatment of dogs with high-grade B-cell lymphoma. Vet Comp Oncol. 2022 Jul 4. doi: 10.1111/vco.12847. Epub ahead of print. PMID: 35789057.

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A group effort leads to a cure for lab with lymphoma

Lorna Welde’s beloved black lab Galaxie developed golf ball size lumps all over his body literally overnight. Cornell University Hospital for Animals (CUHA) diagnosed five-year-old Galaxie with B-cell lymphoma, one of the most common types of cancers in dogs. Welde and her kids started doing research and learned that it was possible for dogs with certain cancers to have bone marrow transplants, though it is a rare procedure. Cornell does not perform bone marrow transplants, but the oncology team supported the family’s decision to have the procedure done at a veterinary hospital in Bellingham, Washington, by Dr. Edmund Sullivan, considered a pioneer in bone marrow transplants in dogs.

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We’re devoted to the fight against canine cancer

Here is a short video of the dogs we’ve helped who are now in remission after treatment of adoptive t-cell therapy and/or bone marrow transplantation.

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Innovative therapy puts Blaine dog’s cancer into remission

When Jackie Craig got her dog Wiley from a ranch when he was eight weeks old, she expected him to have a long, healthy life. That’s because he’s a Blue Heeler, a type of Australian Cattle Dog known for its long, healthy lifespan and lack of predisposed conditions. Wiley quickly became a beloved figure at The Hair Shop on Martin Street in Blaine where Craig works. “He’s the barbershop dog,” she said. “Everybody knows him.”

So it came as a shock when Wiley, at the age of seven and a half, was diagnosed with lymphoma in August last year.

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Trendy pet diets might lack essential nutrients

Adopting trendy diets for pets can lead to nutritional deficiencies, says veterinary nutritionist Valerie Parker. Grain-free, vegan and raw diets have been shown to be inadequate and sometimes risky, and “consulting your veterinarian is the best way to ensure your pet is eating a healthy, balanced diet,” Dr. Parker says.

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U. of Wash. project integrates veterinary, health care for homeless

The University of Washington’s Center for One Health Research is setting up temporary galleries around Seattle displaying photographs made by people experiencing homelessness with a service animal, emotional support animal or pet. Researchers at the center have also been operating a clinic where people can bring animals for veterinary care and also access resources for their own health.

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T Cell Therapy for Lymphoma In Dogs

If your dog has been diagnosed with B cell lymphoma and it has been determined that they might benefit from immunotherapy, Adoptive T cell Therapy might be an option in the battle against the cancer. Adoptive T cell therapy is thought to be most effective after the first round of chemotherapy and when the patient is in remission.

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T-Cell Therapy in Cancer Treatment

For many years, we have treated cancer with surgery, chemotherapy, and radiation therapy. But lately, immunotherapy—treatment that uses the patient’s own immune system—has grown in importance.

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